When someone says "what's up?", a common response is to give a brief update on your current activities or state of mind. For example, you could say something like "Not much, just finishing up some work for the day" or "Just hanging out at home, watching TV".
Alternatively, you could ask the same question back to the person and see what they are up to. It's also okay to simply say "nothing much, how about you?" or to just respond with a friendly greeting like "Hey, how's it going?".
Ultimately, the key is to be friendly and show interest in the other person, while also keeping the conversation light and informal.
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